Yoneda, in progress. Blood Pressure Variability and Cognitive Functioning: A Systematic Review and Meta-Analysis

Status: 
in progress

Introduction: Several studies indicate that blood pressure variability (BPV) is negatively related to cognitive functioning at the interindividual level, as well as cognitive decline at the intraindividual level. However, a small number of studies report a positive relationship between BPV and cognitive functioning in individuals at high risk of cardiovascular disease. Study features in this field vary considerably, including differences in the health of the participants that are targeted, the number of assessments that are included to calculate variability, the timing between assessments, the way in which variability is calculated, the position of participants during measurement, and the assessment of cognition. The objective of this project is to critically analyze the outcome of research reporting the association between blood pressure variability and cognitive functioning or cognitive status in order to understand which (if any) study characteristics may be contributing to inconsistencies in the field. Data Sources: PsycInfo and Web of Science without language restrictions, including papers published in any year, as well as forward and backward searches of reference lists of included articles and relevant reviews for additional reports.

Methods: Study justification, search strategy, and methodological approach for this research synthesis are documented and pre-registered through the Open Science Framework (OSF), which is publically available for readers (https://osf.io/vmnuq/). PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses; Moher et al., 2009) was used to create the protocol for this systematic review and meta-analysis. Multi-level meta-analysis with random effects and maximum likelihood variance estimation will be applied to examine the cumulative evidence for the association between BPV and cognitive functioning.

Results: In Progress

Discussion: In Progress