Multi-study coordinated meta-analysis of pulmonary functioning and cognitive ability.

A coordinated multi-study analysis of the longitudinal between cognition and grip strength in aging.

Objectives. Grip strength and cognitive function reflect upper body muscle strength and mental capacities. Cross-sectional research has suggested that in old age these two processes are moderately to highly associated, and that an underlying common cause drives this association. Our aim was to synthesize and evaluate longitudinal research addressing whether changes in grip strength are associated with changes in cognitive function in healthy older adults.

Introduction: This study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death. Methods: Analysis of six international longitudinal studies was performed using a coordinated approach. Multistate survival models were used to estimate the transition patterns via different cognitive states. Life expectancies were estimated.

Objectives: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis. This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging.

Background: Cognitive reserve was postulated to explain individual differences in susceptibility to ageing, offering apparent protection to those with higher education. We investigated the association between education and change in memory in early old age. 

This study examines the relationship between retirement and cognitive aging. We build on previous research by exploring how different specifications of retirement that reflect diverse pathways out of the labor market, including reason for leaving the pre-retirement job and duration spent in retirement, impact three domains of cognitive functioning. We further assess how early-life factors, including adolescent cognition, and mid-life work experiences, condition these relationships.

Objectives. Given theoretical and methodological advances that propose hypothesis about change in one or multiple processes, analytical methods for longitudinal data have been developed that provide researchers with various options for analyzing change over time. In this paper, we revisited several latent growth curve models that may be considered to answer questions about repeated measures of continuous variables, which may be operationalized as time-varying covariates or outcomes.

Introduction: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. This project examines this possibility by examining trajectories of personality traits preceding dementia diagnosis in several longitudinal studies of aging.

Social activity is one aspect of an active lifestyle and some evidence indicates it is related to preserved cognitive function in older adulthood. However, the potential mechanisms underlying this association remain unclear. We investigate 4 potential mediational pathways through which social activity may relate to cognitive performance.

Objectives. The present study examined age differences among older adults in the daily co-occurrence of affect and its potential role in buffering the negative effects of health stressors.

Design. Participants were from the Veterans Affairs Normative Aging Study (NAS) and included 249 young-old adults (age = 60–79 years, M=71.6) and 64 old-old adults (age = 80–89, M = 82.9) who completed questionnaires assessing stressors, physical health symptoms, and positive and negative affect on eight consecutive days.

Clinical and population research on dementia and related neurologic conditions, including Alzheimer's disease, faces several unique methodological challenges.

Objectives. To identify statistical methods for harmonization, the procedures aimed at achieving the comparability of previously collected data, which could be used in the context of summary data and individual participant data meta-analysis of cognitive measures.

Study Design and Setting. Environmental scan methods were used to conduct two reviews to identify (1) studies that quantitatively combined data on cognition and (2) general literature on statistical methods for data harmonization. Search results were rapidly screened to identify articles of relevance.

Although early adversity has been linked to worse mental and physical health in adulthood, few studies have investigated the pathways through which positive and negative dimensions of early experiences can jointly influence psychological well-being in later life. This study examined: (a) profiles of early experiences across multiple domains, (b) the relations of these profiles to hedonic and eudaimonic well-being in later life, and (c) whether midlife social support mediated these relations.

Personality traits have emerged as significant contributors to physical and mental health, as well as various economic outcomes including income. Few studies have explored whether personality is related to the frequency of days lost on the job due to physical or mental health issues, and the subsequent economic losses as a result. The current study bridged the health, economic, and personality variables to determine whether personality was associated with earnings lost due to work cut back days from poor physical or mental health.

Education is a fundamental cause of social inequalities in health because it influences the distribution of resources, including money, knowledge, power, prestige, and beneficial social connections, that can be used in situ to influence health. Recent studies have highlighted early-life cognition as commonly indicating the propensity for educational attainment and determining health and age of mortality. Health behaviors provide a plausible mechanism linking both education and cognition to later-life health and mortality.

Background: The DNA methylation-based ‘epigenetic clock’ correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.

This study examined the socioeconomic pathways linking partnership status to physical functioning, assessed using objective measures of late life physical functioning, including peak flow and grip strength. Using Wave 4 of the Survey of Health, Ageing and Retirement in Europe (SHARE), we ran multilevel models to examine the relationship between partnership status and physical function in late life, adjusting for social-network characteristics, socioeconomic factors, and health behaviours. We found a robust relationship between partnership status and physical function.

Background: The investigation of multimorbidity and aging is complex and highly intertwined with aging-related changes in physical and cognitive capabilities, and mental health and is known to affect psychological distress and quality of life. Under these circumstances it is important to understand how the effects of chronic conditions evolve over time relative to aging-related and end-of-life changes.

The Positive and Negative Affect Schedule (PANAS) is a widely used measure of emotional experience. The factor structure of the PANAS has been examined predominantly with cross-sectional designs, which fails to disaggregate within-person variation from between-person differences. There is still uncertainty as to the factor structure of positive and negative affect and whether they constitute 2 distinct independent factors.

Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of aging. A coordinated analysis approach is used to compare patterns of change conditional on sample composition differences related to age, sex, and education. Such coordination accelerates evaluation of particular hypotheses. In particular, we focus on the effect of educational attainment on cognitive decline.

Student service members/veterans represent a growing population on college campuses. Despite this growth, scholarly investigations into their health- and adjustment-related issues are almost nonexistent. The limited research that is available suggests that student service members/veterans may have trouble connecting with their civilian counterparts and be at risk for social isolation.

Objectives. Evidence suggests a predictive association between emotion and mortality risk. However, no study has examined dynamic aspects of emotion in relation to mortality. This study used an index of emotional reactivity, defined as changes in positive or negative affect in response to daily stressors, to predict 10-year survival.

Social activity is typically viewed as part of an engaged lifestyle that may help mitigate the deleterious effects of advanced age on cognitive function. As such, social activity has been examined in relation to cognitive abilities later in life. However, longitudinal evidence for this hypothesis thus far remains inconclusive. The current study sought to clarify the relationship between social activity and cognitive function over time using a coordinated data analysis approach across four longitudinal studies.

Engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills, thereby minimizing age-related cognitive decline. While the idea that there may be a modifiable behavior that could lower risk for cognitive decline is appealing and potentially empowering for older adults, research findings have not consistently supported the beneficial effects of engaging in cognitively stimulating tasks.

Past work has demonstrated that Big Five personality traits both predict relationship success and respond to changes in relationship status. The current study extends this work by examining how developments on the Big Five traits correspond to another important social outcome in adulthood, social well-being. Using the Mid-Life Development in the U.S. longitudinal data sample of adults, the authors examined traits and social well-being at two time points, roughly 9 years apart. Results find support for two primary claims.

We investigated the power to detect variances and covariances in rates of change in the context of existing longitudinal studies using linear bivariate growth curve models. Power was estimated by means of Monte Carlo simulations. Our findings show that typical longitudinal study designs have substantial power to detect both variances and covariances among rates of change in a variety of cognitive, physical functioning, and mental health outcomes.

Midlife hypertension is associated with increased risk of cognitive impairment in later life. The association between blood pressure (BP) in older ages and cognition is less clear. In this study we provide estimates of between-person and within-person associations of BP and cognition in a population-based sample (N = 382) followed from age 70 across 12 occasions over 30 years. Between-person associations refer to how individual differences in BP relates to individual differences in cognition.

Background: Educational attainment is highly correlated with social inequalities in adult cognitive health; however, the nature of this correlation is in dispute. Recently, researchers have argued that educational inequalities are an artefact of selection by individual differences in prior cognitive ability, which both drives educational attainment and tracks across the rest of the life course.

In this chapter, we consider alternative temporal sampling designs within the interrupted time series family and explore other potential designs based on decisions about sufficient or optimal time scales capturing particular processes. We refer to this framework as time-scale-dependent longitudinal design (TDLD). A key objective is to provide a basis for researchers to develop studies of process that effectively utilize multiple time scales and intensive measurements.

In this chapter we discuss a variety of issues concerning designed, measurements, and analysis of data from quasi-experimental studies with thte main aim of identifying and explaining individual differences in developmental processes.

The study of change rests on the assumption that observed differences in measurements over time reflect true change in the construct being measured. If measurement properties change over time, there is a threat to internal validity, which results in ambiguity in the conclusions about change.

This supplemental issue of The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences is based on papers presented at a conference on “Cognition, Health, and Aging: Integrating Perspectives across Disciplines” held at Pennsylvania State University, October 30– 31, 2009.

Although longitudinal designs are the only way in which age changes can be directly observed, a recurrent criticism involves to what extent retest effects may downwardly bias estimates of true age-related cognitive change. Considerable attention has been given to the problem of retest effects within mixed effects models that include separate parameters for longitudinal change over time (usually specified as a function of age) and for the impact of retest (specified as a function of number of exposures).

Researchers who study human development are interested in how psychological, physiological, and behavioral phenomena change over time in aging individuals. In fact, Baltes and Nesselroade (1979) identified the primary objective of longitudinal developmental research as the “direct identification of intraindividual change” (p. 23). However, this goal is complicated by the possibility that observable change in any given individual may reflect the joint influences of multiple processes.

The study of aging demands an integrative life-span developmental framework, involving interdisciplinary collaborations and multiple methodological approaches for understanding how and why individuals change, in both normative and idiosyncratic ways. We highlight and summarize some of the issues encountered when conducting integrative research for understanding aging-related change, including, the integration of results across different levels of analysis; the integration of theory, design, and analysis; and the synthesis of results across studies of aging.

Replication of research findings across independent longitudinal studies is essential for a cumulative and innovative developmental science. Meta-analysis of longitudinal studies is often limited by the amount of published information on particular research questions, the complexity of longitudinal designs and the sophistication of analyses, and practical limits on full reporting of results. In many cases, cross-study differences in sample composition and measurements impede or lessen the utility of pooled data analysis.

As the authors describe in this chapter, numerous calls have been made for increased collaboration as a means to focus developmental research on within-person processes. The authors highlight and summarize some examples of collaborative and coordinated research, and the authors elaborate on some fundamental ideas for implementing strategies for maximizing our understanding of within person aging-related changes.

Although elevated rates of parent psychosocial distress have been associated with child behavior and emotional problems, little is known about the nature of this relationship over time. This study followed an epidemiological cohort of children and adolescents over 11 years with 4 waves of data collection. Within this cohort, complete data were available on 238 mothers and their children. Behavior and emotional problems were assessed using the DBC, maternal mental health with the GHQ. Multivariate growth curve modelling was used to evaluate the commonality of individual change patterns.